Atrial cardiomyocyte tachycardia alters cardiac fibroblast function: A novel consideration in atrial remodeling☆
نویسندگان
چکیده
منابع مشابه
Atrial cardiomyocyte tachycardia alters cardiac fibroblast function: a novel consideration in atrial remodeling.
OBJECTIVE Atrial fibrillation (AF) causes tachycardia-induced atrial electrical remodeling, contributing to the progressive nature of the arrhythmia. Ventricular dysfunction due to a rapid response to AF can cause structural remodeling, but whether AF itself directly promotes atrial fibrosis is controversial. This study investigated the hypothesis that rapid atrial cardiomyocyte activation prod...
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introduction atrial standstill is a rare condition, characterized by absence of atrial electrical and mechanical activity evident in surface electrocardiography echocardiography, or fluoroscopy, which is associated with unresponsiveness of atria to maximal output electrical stimulation. this condition can be present with thromboembolic complication, low cardiac output, and sometimes palpitation...
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BACKGROUND There are many similarities between atrial effects of atrial tachycardia remodeling (ATR) and vagal nerve stimulation (VS): both promote atrial fibrillation (AF), reduce atrial effective refractory period (AERP) and AERP rate accommodation, enhance AERP heterogeneity, and increase inward-rectifier K+ current. OBJECTIVE This study sought to compare the consequences of ATR and VS at ...
متن کاملAtrial ionic remodeling induced by atrial tachycardia in the presence of congestive heart failure.
BACKGROUND Atrial fibrillation (AF) and congestive heart failure (CHF) produce discrete forms of atrial ionic remodeling. The in vivo effects of atrial tachycardia (AT) remodeling are altered by CHF. This study evaluated underlying mechanisms at the level of ionic remodeling. METHODS AND RESULTS We studied 4 groups of dogs: (1) unpaced controls (CTLs); (2) CHF caused by 2-week ventricular tac...
متن کاملMultiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs.
BACKGROUND Atrial fibrillation impairs atrial contractility, inducing atrial stunning that promotes thromboembolic stroke. Action potential (AP)-prolonging drugs are reported to normalize atrial hypocontractility caused by atrial tachycardia remodeling (ATR). Here, we addressed the role of AP duration (APD) changes in ATR-induced hypocontractility. METHODS AND RESULTS ATR (7-day tachypacing) ...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2007
ISSN: 0008-6363
DOI: 10.1016/j.cardiores.2007.07.013